Dan K. I'm not applying to a million jobs, and only getting 2-6 people usually per company to email. So I don't think domain reputation will be am issue. It is my personal Gmail with a million years of sending history.
Joe R. I haven't had lookup timing issues, because I have conditions on all my writes and lookups. Usually I'm writing the results into a table and then after that table runs, doing the lookup last.
Just be sure to have a column in the table that is like a unique project ID. That way you pass that ID along in every single data the data moves through, so you can look up data anywhere you need to find it.