Hey Tim, there is no clear answer to this but the below note could be helpful
reply rate = function of (email deliverability, content, problem, audience)
Let me address each one of these
Content - no matter how bad the content is if the problem & solution are right then you would see good reply rates. we tested personalised vs bulk blast both fetched almost same result (1.5% reply rate and 2% reply rate)
Email deliverability - most important and if not maintained properly then this keeps becoming a headache. we used to struggle with this a lot then onboarded an agency which did a fantastic job (life saver tbh)
Problem - More the burning problem the better reply rates are. If the problem is not genuine then the best copies too would not fetch replies
Audience - Who you are reaching out to also plays an important role. If the audience you have fed into the campaign is not relevant, will have a direct impact on your campaign results