Building Efficient Company Lists for Cold Outbound Strategy

I'm trying to carve out a process for building net new company lists for our cold outbound motion - de-duped against accounts in our CRM and based off a list of our high value customers. I took a pass at running the Ocean.io enrichment against the high value list, but de-duping against accounts in CRM meant exporting, sharing with revops, and then bringing the revised list back in. I'd prefer to use the CRM account list to avoid duplication from the start, but the list I have is ~240k rows so it won't fit in one table. Is it possible to have an enrichment reference multiple tables (eg. if I split out the list into multiple parts) when it runs? The vision is to run the Ocean.io enrichment vs. the high value customer companies, and exclude the CRM account companies from the results but I'm not really sure if that's realistic.